The patients were randomly divided (bias coin randomization) into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 μg vit B12, melatonin 1mg, Extrafolate-S 600 μg) once a day 1 hour before sleep, during the 3 months. The study included 60 patients diagnosed with insomnia who refused to take drugs for insomnia and have a positive attitude towards the supplements. Our study aimed to evaluate the efficacy of Magnesium-melatonin-vitamin B complex supplement in the treatment of insomnia. Contrary to that, there is clear evidence on the antidepressant effect of vitamin B12 and vitamin B6 for therapy of hormone-related depression in women. The recent results showed mixed effects of vitamin B 12 on sleep patterns and promoting an effect of vitamin B6 on the reduction of psychological distress, which could induce sleep disturbance. Recent studies suggest that the MT 2 receptor is implicated in the antidepressant-like effects of melatonin. Melatonin and the nonselective MT 1 / MT 2 receptor agonist agomelatine have displayed anxiolytic-like action and have been used in the elderly, but exact mechanisms of action are still unknown. A meta-analysis of 34 studies concluded that insomnia is significantly associated with an increased risk of depression, which has implications for the prevention of depression in non-depressed individuals with insomnia symptoms. According to the National Sleep Foundation, insomnia promotes depression and depression-induced insomnia.
Existing evidence is suggestive of a beneficial effect of Mg on subjective anxiety in anxiety vulnerable samples, and for mild-to-moderate depression in adults within 2 weeks. According to Australia’s Sleep Health Foundation, anxiety and worrying are leading causes of insomnia. Anxiety can cause insomnia, and vice versa which can result in a self-perpetuating cycle, which leads to chronic insomnia. Dietary magnesium intake may have long-term benefits in reducing the likelihood of daytime falling asleep in women. Magnesium supplementation improves sleep efficiency, sleep time and sleep onset latency, early morning awakening, and insomnia objective measures such as the concentration of serum renin, melatonin, and serum cortisol, in older adults. Circadian rhythms dysregulation and compromised lifestyle also increase magnesium excretion, leading to deficiency. Magnesium is a muscle relaxant and inducer of the deeper sleep. įew sleep-promoting nutrients enhance sleep and relaxation. Research indicates that melatonin may shorten the time it takes to fall asleep, increase overall sleep amounts, and may increase REM sleep,. Studies are inconclusive regarding whether melatonin can help treat insomnia in adults, but melatonin could promote sleep by helping to regulate the body’s bio clock and sleep-wake cycles and to adhere to more healthful sleep patterns. The hormone melatonin is produced during the sleep cycle. Mel1 and Mel2 receptor agonist ramelteon and melatonin. Our founding’s indicating that 3 months of the Magnesium- melatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause. Mean AIS score after 3 months of the Magnesium- melatonin- vitamin B complex supplementation was 10.50 ± 4.21 corresponding to mild insomnia, while median AIS score in the control group was 15.13 ± 3.76 which is referred to moderate insomnia, and difference among groups was significant (p = 0.000). Mean AIS score at zero points was 14.93 ± 3.778 in the study group and 14.37 ± 4.081 in the control group (p = 0.476), indicating the compatibility of the groups, and both scores correspond to mild to moderate insomnia. The severity of insomnia symptoms was measured by self-reported Athens insomnia scale (AIS), with a cut-off score by Soldatos (AIS score ≥ 6). The patients were randomly divided into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains 175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 μg vit B12, melatonin 1 mg, Extrafolate-S 600 μg) once a day 1 hour before sleep, during the 3 months.
The study included 60 patients diagnosed with insomnia. Our study aimed to evaluate the efficacy of Magnesium- melatonin-vitamin B complex supplement in the treatment of insomnia. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. Insomnia means difficulty in falling asleep and/or stays asleep.
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